Abstract   

    Thirty-two adult riverine buffaloes (Buhalis bubalus) in their last trimester of pregnancy were selected and randomly divided into four groups. The buffaloes of group I served as control. Animals in group II, III and IV were treated twice (7 days apart) with levamisole hydrochloride (0.5mg/kg b. w. orally), Etosol (Vit E+Se, 10ml, I/m) and Bacilli Calmette Guerine (BCG) (0.5 mi/animal, s/c), respectively. Blood samples were collected at weekly intervals starting day 0 untill parturition. Total erythrocytic count and packed cell volume values were higher (P<0.05) in levamisole and vit E+Se treated group of buffaloes. Haemoglobin concentration was higher (P<0.05) inVit E+Se treated group. MCV. MCH and MCHC remained unchanged among all the experimental groups. Total leukocyte count was higher (P<0.05) in levamisole treated group of buffaloes. Differential leukocyte counts (relative) revealed moderate lymphocytosis in all immunomodulated groups with significantly higher counts in Vit E+Se treated buffaloes. It was inferred that levamisole and vit E-se altered some haematological values, whereas BCGdid not affect the haematological parameters.    

Key words: Haelnatological profile, immunomodulation, gestation, buffalo.