EVALUATION OF: DIURETIC ACTIVITY OF ACHYRANTHES ASPERA (CHIRCHITA) IN GOATS

Nazish Jahan, Riaz Ahmad and ¹Faqir Hussain

Department Chemistry, ¹Department of Physiology and Pharmacology, University of Agriculture Faisalabad

Abstract   

    The investigations were carried out to evaluate the diuretic activity by oral administration of aqueous extract of Achyranthes aspera (Chirchita) at dose Level of 3.00 g/kg b.wt. in goats. Furosemide at dose level of 5.0 mg/kg b.wt. was used as standard diuretic drug. The effects of Achvranthes aspera on diuresis, pH, creatinine, urea and electrolytes (Na⁺, K⁺, Cl^-, HCO₃) in blood and urine samples were studied. The plant extract treated goats showed high diuretic effect as compared to control but this effect was less than furosemide. Significant increase in renal clearance of sodium, potassium, chloride and bicarbonate was observed in plant extract treated and furosemide treated goats.    

Key words: Diuretic activity, Achyronthes aspera goats