This report describes the lower urinary tract disease (LUTD) in four male cats with two different etiologies. All animals were under three years of age and on commercial dry diet. Treatment guidelines prescribed for obstructive and non-obstructive cases were followed. This appears to be the first clinical report on feline LUTD in Pakistan.

Key words: Calcium oxalate dihydrate, Enrofloxacin, Escherichia coli, Struvite, Urethral plug