This work aimed to evaluate the ameliorating effect of grape seed oil (GSO) on the lesions of experimental Acrylamide (ACR) intoxication in male rat genital organs. Two experimental groups of concomitant administration of 2 dietary levels of GSO with the toxic dose of ACR were evaluated in comparison with a negative control group and other 3 positive control groups for each of the 2 dietary levels of GSO and the toxic dose of the ACR. The results, at the end of the experiment (3 weeks), revealed occurrence of the highest scale of the histopathologic changes in case of the group of ACR-intoxication. These changes were in the form of testicular degeneration, abnormal epididymal contents of immature spermatocytes and multinucleated giant cells. The prostate glands and seminal vesicles showed cystic dilatation with less secretory materials, epithelial hyperplasia, necrosis and desquamation. Nearly similar scales of lesions were seen in the group administrated by ACR with low levels of GSO, while the lesions in the other group of administration by ACR with the high levels of GSO were of less scales. The conclusion from this microscopic evaluation was the occurrence of a less and level-dependent impact ameliorating effect of GSO supplementation against ACR-induced lesions in male genital organs of the adult rats.

Key words: Acrylamide, Ameliorating effect, Epididymis, Grape seed oil, Prostate gland, Seminal vesicle, Testis