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Immunomodulatory Activity of β-glucan and Mannan-Oligosaccharides from Saccharomyces cerevisiae on Broiler Chickens Challenged with Feed-Borne Aspergillus fumigatus
Liangcheng Chen1*, Tao Jiang2, Xiao Li1, Qi Wang1, Yongqiang Wang1* and Yu Li1
1Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun, Jilin, China 130118; 2China-Japan Union Hospital of Jilin University, Changchun, Jilin, China 130118; *Corresponding author:;


Aspergillus fumigatus (A. fumigatus), a common feed contaminant particularly ubiquitous in conserved feeds, poses a potential health risk of intestinal health in broilers. The aim of this work was to assess the effects of dietary supplementation with β-glucan (BG) and mannan-oligosaccharides (MOS) from Saccharomyces cerevisiae (S. cerevisiae) on broiler chickens’ production and health, especially under the challenge of naturally feed-borne A. fumigatus.  The study includes one control group fed with regular feed and two supplement-treated groups fed with BG and MOS. The results showed broilers in treatment groups had lower mortality rate and higher antibody titers of Newcastle disease virus (NDV), compared with control group. The immunological analysis found that, when broiler chickens were challenged with A. fumigatus, spleen and thymus indices were markedly improved, the cytokine concentrations in serum were increased, and the activities of heterophils and lymphocytes were up-regulated when the feed was supplemented with BG and MOS.  These data suggest this dietary supplement not only overcomes the negative effect of A. fumigatus, but also improves the production and heath of broiler chickens by up-regulating the immune function in broiler chickens.

Key words: Aspergillus fumigatus, Broilers, Heterophils, Immunomodulatory, β-glucan, mannan-oligosaccharides


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)