The present study was designed to observe the toxic effects of sodium arsenite on serum biochemical constituents and liver parenchyma along with amelioration with vitamin E in teddy bucks. Adult sixteen bucks were purchased from the market and divided into four groups with specific treatments for 84 days; A (control), B (sodium arsenite 5mg/kg BW), C (Sodium arsenite 5mg/kg BW +Vit E 200mg/kg BW) and D (Vit E 200mg/kg BW). The serum biochemical parameters were evaluated fortnightly.  Analysis of data revealed that there was significant P<0.05 rise in alanine aminotransferase (ALT), aspartate transaminase (AST), glucose and total cholesterol in arsenic treated animals. After slaughtering of animals, visceral organs were observed for gross lesions and processed for histopathologically studies.  The major histopathological changes were congestions, pyknosis and cytoplasmic vacuolation in liver.    Supplementation of vitamin E along with sodium arsenite alleviated the toxic effects on ALT, AST, glucose and total cholesterol level as well as histopathology of liver. It was concluded from the present study that sodium arsenite causes the toxicity in teddy bucks and vitamin E has the ameliorative effects on these toxic effects of arsenic.

Key words: Liver, Serum, Sodium arsenite, Teddy bucks