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Hematological and Serum Biochemical Effects of Aflatoxin B1 Intoxication in Broilers Experimentally Infected with Fowl Adenovirus-4 (FAdV-4)
Muhammad Noman Naseem1, Muhammad Kashif Saleemi1*, Rao Zahid Abbas2, Ahrar Khan1, Aisha Khatoon1, Shafia Tehseen Gul1, Muhammad Imran1, Zia-ud-Din Sindhu2 and Asim Sultan3
1Department of Pathology, University of Agriculture Faisalabad; 2Department of Parasitology, University of Agriculture Faisalabad; 3Livestock and Dairy Development Department, Faisalabad, Punjab Pakistan
*Corresponding author:


Mycotoxins contamination of poultry feeds is a global issue faced by the poultry industry due to increase demand and provision of poor quality cereal grains. The current experimental study was designed to investigate concurrent administration of aflatoxins and fowl adenovirus in commercial broilers. Fowl adenovirus-4 is re-emerging in Pakistan including its horizontal and vertical transmission. A total of 120 one day old birds were divided into six equal groups (A-F). Groups A was kept as control, B and C were fed AFB1 100 and 200 ppb respectively, whereas group D, E and F were administered FAdV-4, AFB1 100 +FAdV-4, AFB1 200 + FAdV-4, respectively. Hemoglobin concentration, erythrocytic count and leukocytic count of all the groups significantly decreased as compared to control group. Hematocrit (%) of group C, E and F was significantly lower as compared to group A. Serum concentration of creatinine, urea, ALT, AST and GGT significantly increased in all groups as compared to control group in a dose dependent manner. It might be concluded that AFB1 intoxication in FAdV-4 infected birds potentiated the hepatic and renal damage as indicated by increased values of urinary and hepatic biomarkers.

To Cite This Article: Naseem MN, Saleemi MK, Abbas RZ, Khan A, Khatoon A, Gul ST, Imran M, Sindhu ZUD and Sultan A, 2018. Hematological and serum biochemical effects of aflatoxin B1 intoxication in broilers experimentally infected with fowl adenovirus-4 (FAdV-4). Pak Vet J, 38(2): 209-213.


ISSN 0253-8318 (Print)
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