Studies on wound healing models in various disciplines of both human and veterinary medicines remain crucial in determining the potential accelerating effects of new drugs and various agents on healing and in providing insights into the mechanisms and pathophysiology of wound repair. Although the complex biological processes of wound healing are well understood, a thorough comprehension of the wound type, size, and impact on the healing process is essential to intervene in these processes effectively. The recovery of anatomical and functional characteristics of injured tissues relies on a comprehensive understanding of differences between wound models and animal species under investigation, which in turn necessitates the development of an appropriate study protocol. The primary objective of a researcher in wound healing is to develop novel methods, strategies, and medical products that intervene in natural wound healing, accelerate recovery, and prevent complications, including aesthetic considerations. To achieve this goal, numerous acute and chronic simulated wound models have been identified, encompassing a wide range of animal species. Nonetheless, wound healing continues to retain its significance and complexity, thereby amplifying the necessity for preclinical (animal model) studies in contemporary research. The reliable outcomes of an experiment depend on the researcher’s meticulous planning regarding which stage of wound healing to intervene and how, the creation of an appropriate wound size and depth and the utilization of suitable wound measurement techniques for evaluating the healing process. This article presents and discusses current information on wound healing, influencing factors and criteria for evaluating the healing process.