The impact of Selenium (Se) and Vitamin E (VE) on physiological and biochemical parameters, secondary hair follicle development, and intestinal microbiota in White cashmere goat ewes and their offspring in Tibet is explored in the current paper. Twelve ewes and their lambs were randomly distributed into an experimental control group (EC) fed a basal diet and an experimentally supplemented group (ESE) supplemented with 0.4mg/kg Se and 200IU/kg VE. Their offspring were then divided into two groups: a lamb control group (LC) and an experimental lamb group (LSE). Lambs in the LSE group possessed a higher content of BUN in blood compared to those in the LC group (P<0.05). Ewes in the ESE group had significantly lower AST activities than ewes in the EC group (P<0.05). ALT activity was significantly higher in the LC group as opposed to that in the LSE group of lambs (P<0.05). Antioxidant capacity indicators, such as T-AOC, T-SOD, GSH-Px, and CAT, were significantly increased in both ewes and lambs after Se and VE supplementation (P<0.05). In the LSE lambs, the number of mature secondary hair follicles and the mature Sf:P ratio were increased (P<0.05), while Se and VE supplementation repressed these parameters in ewes (P<0.05). According to the analysis of microbiota, Se and VE supplementation showed no significant alteration in fecal microbiota composition in cashmere goats, including ewes and lambs. Conclusion: Dietary supplementation of Se and VE enhances antioxidant capacity, improves serum biochemical indices, and develops secondary hair follicles in lambs, further exerting a positive effect on cashmere production performance.

To Cite This Article: Awang C, De J, Ba J, Gesang J, Wu Y, Mohamed RAEH, Essam HI, and Suo L, 2026. Effects of selenium and vitamin E supplementation on physiological, biochemical indicators, and intestinal microbiota of white cashmere goat. Pak Vet J, 46(1): 231-239. http://dx.doi.org/10.29261/pakvetj/2026.013