Mastitis, also known as the inflammation of mammary glands, is a major health threat for bovines leading to severe health and economic losses. A significant drop in the production and quality of milk is the characteristic feature of mastitis. There are more than 135 bacterial species known to contribute to the development of mastitis. Among all bacterial species Staphylococcus aureus, coagulase-negative staphylococci, Escherichia coli, Streptococcus uberis, Streptococcus dysgalactiae, and Streptococcus agalactiae are most reported to cause mastitis. Antimicrobial resistance is a global threat now-a-days because multiple bacterial species have developed resistance against various classes of antimicrobial drugs. Because of the rising issue of antimicrobial resistance, scientists have focused on alternative treatment strategies to overcome this issue. Botanical compounds are well known for their diverse medicinal and biological activities. These properties make them perfect candidates for the treatment of mastitis and the development of new drugs to overcome resistance problem. Flavonoids, saponins, phenolics, and quinones have reported effective mechanisms against mastitis. In this review, we will briefly discuss the pathogenesis of mastitis and different mechanisms of various botanical compounds in order to formulate new potential alternative drugs.

To Cite This Article: Xia N, Chen B, He Q, Fu Y, Gu X, Sun J, Qu W, Wu X, Guo X, Mehmood K and Wu Y 2025. Prevention and treatment effects of herbal medicine on bovine mastitis. Pak Vet J, 45(3): 983-992. http://dx.doi.org/10.29261/pakvetj/2025.264