Leishmaniasis is a tropical and subtropical disease caused by protozoan parasites of the genus Leishmania and represents a serious public health threat in many endemic regions of the world. The main therapeutic interventions used to control leishmaniasis are based on pentavalent antimonials and amphotericin B, which are characterized by high toxicity, restrictive prices, and selection of drug-resistant strains. To avoid these drawbacks of conventional therapeutics, we are in dire need to develop new, efficient, and safe therapeutic options. Among all the alternative control and preventive strategies for leishmaniasis nanotechnology is found most promising. There are multiple types of nanoparticles, but silver nanoparticles (AgNPS) have been reported to have most potent results in controlling leishmaniasis. In this article, we review the limitations of conventional antileishmanial drugs, antileishmanial properties and mechanism of actions of AgNPs.

To Cite This Article: Alawfi BS, 2026. Role of silver nanoparticles as an alternative control strategy for the control of leishmaniasis disease a public health concern. Pak Vet J, 46(5): 1056-1065. http://dx.doi.org/10.29261/pakvetj/2026.096